Peptide Ligand-Based Affinity Purification process runs as in the following drawing
Why Choose Our Novel Peptide Ligand Technology for Therapeutic Antibody and Protein Purification?
The growing demand for therapeutic biologics, including monoclonal antibodies (mAbs) and non-antibody proteins, highlights the urgent need for efficient and scalable downstream purification technologies. While upstream production methods have advanced significantly, purification processes still depend heavily on Protein A/G and antibody-based affinity chromatography. Although effective in certain applications, these conventional ligands face significant limitations, including high production costs, limited stability under harsh cleaning conditions, short operational lifespans, and vulnerability to proteolytic degradation.
Traditional affinity ligands—such as antibodies, antibody fragments, small molecules, nucleic acid aptamers, and globular proteins like Protein A/G—are not universally suitable for all conditions. Larger ligands, including Protein A/G and antibody fragments, are particularly susceptible to proteolytic degradation, which can compromise their performance and potentially release immunogenic fragments into purified products, raising safety concerns. Meanwhile, smaller ligands like nucleic acid aptamers (short single-stranded DNA or RNA oligonucleotides) and small molecules, while offering specificity, often lack robustness in complex biological environments, suffer from non-specific interactions with host cell proteins, or require extensive chemical modifications to enhance their stability.
These inherent challenges underscore the need for innovative affinity ligands that combine robustness, scalability, and specificity to meet the evolving demands of biologics purification. Our peptide-based affinity ligands are engineered to address these limitations, offering superior performance and reliability across diverse bioprocessing conditions.
Our groundbreaking technology is based on the development of novel protease-resistant peptide ligands tailored for therapeutic biologics purification. These ligands provide a transformative alternative to conventional affinity purification methods by offering the following unparalleled advantages:
- Cost-Effectiveness: Our peptide ligands reduce overall costs by eliminating the need for expensive protease inhibitors and providing a more economical alternative to Protein A/G chromatography.
- Enhanced Stability, Selectivity, Affinity, and Yield: Immobilized on agarose-based chromatographic supports via stable amide or thioether bonds, these ligands offer exceptional chemical stability, superior binding efficiency, and high selectivity. This ensures high recovery rates and unparalleled purity of target proteins and antibodies, even under low-stringency conditions.
- Extended Matrix Lifespan: The protease-resistant design significantly increases the durability of purification matrices, reducing replacement frequency and lowering operational costs.
- Protease Resistance: These ligands withstand degradation by proteolytic enzymes, such as trypsin and α-chymotrypsin, maintaining their binding performance and preventing the release of immunogenic fragments into purified products.
Innovative Solutions for Purification of Biologics with Peptide Ligands
- While Protein A/G chromatography has revolutionized antibody purification, comparable solutions for purifying diverse biologics in their native, active conformation are limited or come with certain drawbacks.
- Our innovative peptide ligand technology addresses this challenge, enabling robust, selective, and scalable purification of a wide range of therapeutic proteins, such as enzymes, hormones, and other biologics, while preserving their native, active state under mild or low elution conditions.
- By combining rational design, high-throughput screening, and systematic validation, we provide customized affinity capture solutions that are tailored to the specific needs of your downstream bioprocessing workflows. These solutions enhance process robustness, reduce manufacturing costs, and accelerate development timelines for your pharmaceutical pipeline.
- With our advanced peptide ligand technology, you can overcome the challenges of biologics purification, ensuring the consistent delivery of high-quality therapeutic products to patients worldwide.
Why work with us
Customer service
We offer high-quality products and stand for trusting and long-term partnerships.
Our customers value our broad knowledge, our experience and our expertise in the field of peptide development and production.
Reliability
Quality Manager ensures that production remains at the highest level through development, quality control and regulatory processes
Sustainability
We believe that ethical behavior and integrity are essential to long-term corporate success. That's why we continually monitor and improve our social, economic and environmental performance.